Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater


Journal article


Abagail K Williams*, Joshua Tropp*, Erin R Crater, Naresh Eedugurala, Jason D Azoulay, (* denotes co-first)
ACS Applied Polymer Materials, vol. 1(3), 2019, pp. 309–314


Cite

Cite

APA   Click to copy
Williams*, A. K., Tropp*, J., Crater, E. R., Eedugurala, N., Azoulay, J. D., & denotes co-first), (*. (2019). Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater. ACS Applied Polymer Materials, 1(3), 309–314. https://doi.org/10.1021/acsapm.8b00064


Chicago/Turabian   Click to copy
Williams*, Abagail K, Joshua Tropp*, Erin R Crater, Naresh Eedugurala, Jason D Azoulay, and (* denotes co-first). “Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater.” ACS Applied Polymer Materials 1, no. 3 (2019): 309–314.


MLA   Click to copy
Williams*, Abagail K., et al. “Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater.” ACS Applied Polymer Materials, vol. 1, no. 3, 2019, pp. 309–14, doi:10.1021/acsapm.8b00064.


BibTeX   Click to copy

@article{abagail2019a,
  title = {Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater},
  year = {2019},
  issue = {3},
  journal = {ACS Applied Polymer Materials},
  pages = {309–314},
  volume = {1},
  doi = {10.1021/acsapm.8b00064},
  author = {Williams*, Abagail K and Tropp*, Joshua and Crater, Erin R and Eedugurala, Naresh and Azoulay, Jason D and denotes co-first), (*}
}

The evolution of conjugated polyelectrolytes (CPEs) that transduce analyte–receptor interactions into detectable fluorescent responses in complex aqueous environments is predicated on advancements in molecular design and improved synthetic accessibility. Here, we demonstrate a simple post-polymerization modification protocol, based on thiol–ene click chemistry, that results in the rapid installation of sodium sulfate terminated side-chains to a poly(fluorene-co-ethynyl) scaffold. The fluorescence of the resulting water-soluble CPE is quenched by Fe3+, dequenched selectively by pyrophosphate (PPi), and accurately quantifies PPi within ±6 nM in artificial seawater. The broad utility of thiol–ene click chemistry should offer the straightforward integration of diverse sensing elements.




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