Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing

Journal article

Ryan P. Trueman, Owein Guillemot-Legris, Henry T. Lancashire, Abijeet S. Mehta, Joshua Tropp, Rachel E. Daso, Jonathan Rivnay, Alethea B. Tabor, James B. Phillips, Bob C. Schroeder
Adv. Eng. Mater., vol. 26(6), 2024 Mar 1, p. 2301488

DOI: 10.1002/adem.202301488

Cite

APA Click to copy
Trueman, R. P., Guillemot-Legris, O., Lancashire, H. T., Mehta, A. S., Tropp, J., Daso, R. E., … Schroeder, B. C. (2024). Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing. Adv. Eng. Mater., 26(6), 2301488. https://doi.org/10.1002/adem.202301488

Chicago/Turabian Click to copy
Trueman, Ryan P., Owein Guillemot-Legris, Henry T. Lancashire, Abijeet S. Mehta, Joshua Tropp, Rachel E. Daso, Jonathan Rivnay, Alethea B. Tabor, James B. Phillips, and Bob C. Schroeder. “Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing.” Adv. Eng. Mater. 26, no. 6 (March 1, 2024): 2301488.

MLA Click to copy
Trueman, Ryan P., et al. “Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing.” Adv. Eng. Mater., vol. 26, no. 6, Mar. 2024, p. 2301488, doi:10.1002/adem.202301488.

BibTeX Click to copy

@article{ryan2024a,
  title = {Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing},
  year = {2024},
  month = mar,
  day = {1},
  issue = {6},
  journal = {Adv. Eng. Mater.},
  pages = {2301488},
  volume = {26},
  doi = {10.1002/adem.202301488},
  author = {Trueman, Ryan P. and Guillemot-Legris, Owein and Lancashire, Henry T. and Mehta, Abijeet S. and Tropp, Joshua and Daso, Rachel E. and Rivnay, Jonathan and Tabor, Alethea B. and Phillips, James B. and Schroeder, Bob C.},
  month_numeric = {3}
}

Electrical stimulation has shown promise in clinical studies to treat nerve injuries. This work aimed to create an aligned bioelectronic construct that can be used to bridge a nerve gap, directly interfacing with the damaged nerve tissue to support regeneration. The conductive three-dimensional bioelectronic scaffolds described herein are composite materials, comprised of conductive polypyrrole (PPy) nanoparticles embedded in an aligned collagen hydrogel. The bioelectronic constructs were seeded with dorsal root ganglion (DRG) derived primary rat neurons and electrically stimulated in vitro. The PPy loaded constructs supported a 1.7-fold increase in neurite length in comparison to control collagen constructs. Furthermore, upon electrical stimulation of the PPy-collagen construct, a 1.8-fold increase in neurite length was shown. This work illustrates the potential of bioelectronic constructs in neural tissue engineering and lays the groundwork for the development of novel bioelectronic materials for neural interfacing applications.