Versatile Poly(3,4-ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester


Journal article


Joshua Tropp, Abijeet Mehta, Ruiheng Wu, Manideep Reddy, Shiv Patel, Anthony Petty, Jonathan Rivnay
Chem. Mater., vol. 35, 2022, pp. 41-50


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APA   Click to copy
Tropp, J., Mehta, A., Wu, R., Reddy, M., Patel, S., Petty, A., & Rivnay, J. (2022). Versatile Poly(3,4-ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester. Chem. Mater., 35, 41–50. https://doi.org/10.1021/acs.chemmater.2c02315


Chicago/Turabian   Click to copy
Tropp, Joshua, Abijeet Mehta, Ruiheng Wu, Manideep Reddy, Shiv Patel, Anthony Petty, and Jonathan Rivnay. “Versatile Poly(3,4-Ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester.” Chem. Mater. 35 (2022): 41–50.


MLA   Click to copy
Tropp, Joshua, et al. “Versatile Poly(3,4-Ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester.” Chem. Mater., vol. 35, 2022, pp. 41–50, doi:10.1021/acs.chemmater.2c02315.


BibTeX   Click to copy

@article{joshua2022a,
  title = {Versatile Poly(3,4-ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester},
  year = {2022},
  journal = {Chem. Mater.},
  pages = {41-50},
  volume = {35},
  doi = {10.1021/acs.chemmater.2c02315},
  author = {Tropp, Joshua and Mehta, Abijeet and Wu, Ruiheng and Reddy, Manideep and Patel, Shiv and Petty, Anthony and Rivnay, Jonathan}
}

The field of bioelectronics leverages the optoelectronic properties of synthetic materials to interface with living systems. These applications require materials that are conductive, aqueous-processible, biocompatible, and can be chemically modified for biofunctionalization. While conjugated polymers and polyelectrolytes have been reported that demonstrate several of these features, materials that offer each of these properties simultaneously are rare. Here, we develop copolymers of anionic polyelectrolyte poly(4-(2,3-dihydrothieno [3,4-b]-[1,4]dioxin-2-yl-methoxy)-1-butanesulfonic acid, sodium salt) (PEDOT-S) containing structural units with amine-reactive N-hydroxysuccinimide (NHS)-esters. The reported PEDOT-NHS copolymers demonstrate water solubility and electrical conductivities similar to previously reported PEDOT-S, as well as the ability to bind important amine-rich biomaterials. Furthermore, the PEDOT-NHS copolymers were biocompatible and hemocompatible and therefore show promise for next-generation bioelectronic and regenerative engineering applications.

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